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The structure and dynamics of jet streaks in the extratroprcal upper troposphere are examrned rn the context of a continuously stratified quasi-geostrophic (QG) framework It is hypothesized that jet streaks may result from the sup...
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The structure and dynamics of jet streaks in the extratroprcal upper troposphere are examrned rn the context of a continuously stratified quasi-geostrophic (QG) framework It is hypothesized that jet streaks may result from the superposition of monopolar or dipolar vortices of mesoscale dimensions with the enhanced potential-vorticity gradients constituting the tropopause. Based on this hypothesis, steady-state monopolar and dipolar vortices in a uniform zonal background flow on an f-plane are investigated for their applicability as idealized dynamical representations of jet streaks. The representations of jet streaks satisfy the nonlinear governing equations of the continuously stratified QG framework: the monopolar vortex is specified in terms of axisymmetric distributions of QG potential vorticity in the interior of the domain and perturbation potential temperature on upper (tropopause) and lower (surface) boundaries, whereas the dipolar vortex is adapted from a closed-form analytical solution for the geostrophic stream function. Through the incorporation of vertical structure and divergent circulations, these representations of jet streaks extend those presented previously by the authors using a non-divergent barotropic model. It is shown thatthese vortex representations display characteristic signatures similar to those observed in atmospheric jet streaks. In particular, both the monopole and the dipole exhibit an ageostrophic wind directed towards lower geopotential height in the entrance region of the streak and towards higher geopotential height in the exit region. For the monopole, this ageostrophic wind is entirely rotational and there is no vertical motion. For the dipole, the rotational part of the ageostrophic wind dominates the divergent part; the latter is associated with a four-cell pattern of vertical velocity similar to that described in conceptual models of straight jet streaks. For both the monopole and the dipole, the jet streak is induced by the vortex structure such thatthe wind speed maximum translates at the same speed as the individual vortices; this translation speed is slower than the maximum wind speed in the core of the speed maximum, consistent with observations of jet streaks. It is proposed that the above representations provide a formal theoretical foundation for the conceptual models of jet streaks prevalent in the literature; these conceptual models typically are based on heuristic kinematic or parcel arguments and not on consistent solutions to a physically plausible set of equations. The representations also provide a foundation upon which to explore the unsteady behaviour of jet streaks in terms of the superposition of monopolar and dipolar vortices with non-uniform zonal background flows.
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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and...
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The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) antibody neutralization response and its evasion by emerging viral variants and variant of concern (VOC) are unknown, but critical to understand reinfection risk and breakthrough infection following vaccination. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus–cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples from 233 reverse transcription polymerase chain reaction (RT-PCR)–confirmed Coronavirus Disease 2019 (COVID-19) individuals with detailed demographics and followed up to 7 months. A broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization, was associated with COVID-19 severity. A subgroup of “high responders” maintained high neutralizing responses over time, representing ideal convalescent plasma donors. Antibodies generated against SARS-CoV-2 during the first COVID-19 wave had reduced immunoreactivity and neutralization potency to emerging Spike variants and VOC. Accurate monitoring of SARS-CoV-2 antibody responses would be essential for selection of optimal responders and vaccine monitoring and design.
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Recent observations in the Sea of Japan show evidence of convection to a depth of roughly 1000 m in the winter of 2000, situated along the polar front. Numerical simulations have shown that this deep mixing is associated with both...
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Recent observations in the Sea of Japan show evidence of convection to a depth of roughly 1000 m in the winter of 2000, situated along the polar front. Numerical simulations have shown that this deep mixing is associated with both ageostrophic frontal circulations and pre-existing larger-scale downwelling regimes. The downwelling regimes appear to be a result of interactions between frontal meandering and deep circulation in this basin over bottom topography anomalies. The coupling between the frontal dynamics and the deep circulation are explored by analogy to atmospheric frontal circulations through the semigeostrophic Sawyer-Eliassen equation, solved numerically for the case of the Sea of Japan. As in the atmospheric case, a vertical coupling between the upper and lower circulations can produce a localized region of downwelling that can be conducive to deeper mixing than that forced solely from surface fluxes.
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Numerical simulations using a fire model, FIRETEC, coupled to an atmospheric dynamics model, HIGRAD, are examined to investigate several fundamental aspects of fire behavior in grasslands, and specifically the dependence of this b...
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Numerical simulations using a fire model, FIRETEC, coupled to an atmospheric dynamics model, HIGRAD, are examined to investigate several fundamental aspects of fire behavior in grasslands, and specifically the dependence of this behavior on the ambient atmospheric winds and on the initial length of the fire line. The FIRETEC model is based on a multi-phase transport approach, and incorporates representations of the physical processes that govern wildfires, such as combustion and radiative and convective heat exchange. Results from the coupled model show that the forward spread of the simulated fires increases with increasing ambient wind speed, and the spread rates are consistent with those observed in field experiments of grass fires; however, the forward spread also depends significantly on the initial length of the fire line, and for a given ambient wind speed the spread rate for long (100 m) lines is greater than that for short (16 m) lines. The spread of the simulated fires in the lateral direction also depends on the ambient wind speed and the length of the fire line, and a possible explanation for this effect is given. For weak ambient winds, the shape of the fire perimeter is dramatically different from that seen with higher wind speeds. The shape of the fire perimeter is also shown to depend on the initial length of the fire line. These differences in fire behavior are attributed to the differences in the nature of the coupled atmosphere–fire interactions among these cases, and are described in terms of the complex interplay between radiative and convective heat transfer.
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Numerical simulations using a coupled atmosphere-fire model (called HIGRAD/FIRETEC) are examined to investigate the dynamics of fire behavior in grasslands, focusing specifically on the relative roles and contributions of radiativ...
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Numerical simulations using a coupled atmosphere-fire model (called HIGRAD/FIRETEC) are examined to investigate the dynamics of fire behavior in grasslands, focusing specifically on the relative roles and contributions of radiative and convective heat transfer and the relationships of these processes to the evolution of the solid fuel temperature; the three-dimensional velocity fields in the vicinity of the fire; and the depletion of fuel, fuel moisture, and oxygen. The progression of the fire past a given point in these simulations is divided into a preheating period and an active burning period. The preheating period is characterized by a slowly increasing radiative heating of the fuel that evaporates fuel moisture and raises the temperature of the fuel slightly and by weak convective cooling because the gases flowing over the heated solid fuel are still cooler than the fuel itself. The active burning period is characterized by the presence of a strong pulse of convective heating and continued radiative heating, accompanied by the development of large vertical velocities and a rapid increase in fuel temperature that causes the reaction rates to increase and the fuel to begin to burn, producing heat and increasing the rates of depletion of fuel and oxygen. In all simulations, the magnitude of the convective heat transfer is greater than that of the radiative heat transfer; however, these processes and their relationships to the three-dimensional structure and evolution of the fire are shown to depend both on the ambient wind speed and on the specific location along the fire front (e.g., at the head of the fire where the fire is spreading in the direction of the ambient wind, or on the flank of the fire where the fire is spreading in the direction almost perpendicular to the ambient wind).
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Ocean wind vectors from the SeaWinds scatterometer aboard the Quick Scatterometer (QuikSCAT) satellite and Geostationary Operational Environmental Satellite (GOES) imagery are used to develop an objective technique that can detect...
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Ocean wind vectors from the SeaWinds scatterometer aboard the Quick Scatterometer (QuikSCAT) satellite and Geostationary Operational Environmental Satellite (GOES) imagery are used to develop an objective technique that can detect and monitor tropicaldisturbances associated with the early stages of tropical cyclogenesis in the Atlantic basin. The technique is based on identification of surface vorticity and wind speed signatures that exceed certain threshold magnitudes, with vorticity averaged overan appropriate spatial scale. The threshold values applied herein are determined from the precursors of 15 tropical cyclones during the 1999-2004 Atlantic Ocean hurricane seasons using research-quality QuikSCAT data. The choice of these thresholds is complicated by the lack of suitable validation data. The combination of GOES and QuikSCAT data is used to track the tropical disturbances that are precursors to the 15 tropical cyclones. This combination of data can be used to test detection but is not as easily used to examine false alarms. Tropical disturbances are found for these cases within a range of 19-101 h before classification as tropical cyclones by the National Hurricane Center. The 15 cases are further subdivided based upon their origination source (i.e., easterly wave, upper-level cutoff low, stagnant frontal zone, etc.). The primary focus centers on the cases associated with tropical waves, because these waves account for the majority of all Atlantic tropical cyclones. The detection technique illustrates the ability to track these tropical disturbances from near the coast of Africa. Analysis of the pretropical cyclone (pre-TC) tracks for these cases depicts stages, related to wind speed and precipitation, in the evolution of a tropical disturbance within an easterly wave to a tropical cyclone.
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The structure and dynamics of buoyant plumes arising from surface-based heat sources in a vertically sheared ambient atmospheric flow are examined via simulations of a three-dimensional, compressible numerical model. Simple circul...
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The structure and dynamics of buoyant plumes arising from surface-based heat sources in a vertically sheared ambient atmospheric flow are examined via simulations of a three-dimensional, compressible numerical model. Simple circular heat sources and asymmetric elliptical ring heat sources that are representative of wildland fires of moderate intensity are considered, Several different coherent vortical structures that dominate the plume structure and evolution are evident in the simulations, and these structures correspond well with those observed in plumes from wildland fires For the circular source, these structures include: (i) a counter-rotating vortex pair aligned with the plume trajectory that is associated with a bifurcation of the plume, (ii) transverse shear-layer vortices on the upstream face of the plume, and (iii) vertically oriented wake vortices that form periodically with alternating sign on either side of the downstream edge of the plume base. For the elliptical ring source, a streamwise counter-rotating vortex pair is apparent on each flank, and a transverse horizontal vortex is observed above the head of the source. In all simulations the plume cross section is represented poorly by a self-similar Gaussian distribution.
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Many neurodegenerative diseases have a hallmark regional and cellular pathology. Gene expression analysis of healthy tissues may provide clues to the differences that distinguish resistant and sensitive tissues and cell types. Com...
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Many neurodegenerative diseases have a hallmark regional and cellular pathology. Gene expression analysis of healthy tissues may provide clues to the differences that distinguish resistant and sensitive tissues and cell types. Comparative analysis of gene expression in healthy mouse and human brain provides a framework to explore the ability of mice to model diseases of the human brain. It may also aid in understanding brain evolution and the basis for higher order cognitive abilities. Here we compare gene expression profiles of human motor cortex, caudate nucleus, and cerebellum to one another and identify genes that are more highly expressed in one region relative to another. We separately perform identical analysis on corresponding brain regions from mice. Within each species, we find that the different brain regions have distinctly different expression profiles. Contrasting between the two species shows that regionally enriched genes in one species are generally regionally enriched genes in the other species. Thus, even when considering thousands of genes, the expression ratios in two regions from one species are significantly correlated with expression ratios in the other species. Finally, genes whose expression is higher in one area of the brain relative to the other areas, in other words genes with patterned expression, tend to have greater conservation of nucleotide sequence than more widely expressed genes. Together these observations suggest that region-specific genes have been conserved in the mammalian brain at both the sequence and gene expression levels. Given the general similarity between patterns of gene expression in healthy human and mouse brains, we believe it is reasonable to expect a high degree of concordance between microarray phenotypes of human neurodegenerative diseases and their mouse models. Finally, these data on very divergent species provide context for studies in more closely related species that address questions such as the origins of cognitive differences.
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The overproduction of vascular NO contributes toward the circulatory collapse observed in patients with septic shock. Dimethylarginine dimethylaminohydrolase (DDAH), which has 2 isoforms, metabolizes asymmetrically methylated argi...
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The overproduction of vascular NO contributes toward the circulatory collapse observed in patients with septic shock. Dimethylarginine dimethylaminohydrolase (DDAH), which has 2 isoforms, metabolizes asymmetrically methylated arginines (asymmetric mono- or di-methylarginine), endogenously produced NO synthase inhibitors. We wished to investigate whether reducing DDAH1 activity, using genetic and pharmacological approaches, is protective during lipopolysaccharide-induced endotoxic shock.Experiments were conducted in DDAH1 heterozygous knockout mice (DDAH1(+/-)) or naive rats treated with a synthetic pharmacological DDAH inhibitor (L-257). We demonstrate for the first time that L-257 is DDAH1 selective using recombinant human DDAH proteins. DDAH1 mRNA was expressed in aortic but not macrophage cDNA, and consistent with this expression profile, L-257 selectively inhibited NO production from lipopolysaccharide-treated aorta but not macrophages, in culture. Conscious and anesthetized cardiovascular hemodynamics were monitored using implanted radiotelemetry devices or invasive catheters, respectively. Lipopolysaccharide was administered intravenously to model endotoxemia, and all animals presented with circulatory shock. DDAH1(+/-) mice or L-257-treated rats displayed attenuation in the rate of developed hypotension compared with wild-type littermates or vehicle control animals, respectively.Pharmacological and genetic reduction of DDAH1 activity is protective against the vascular changes observed during endotoxic shock.
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Background & AimsThe World Health Organization (WHO) established targets to eliminate hepatitis C virus (HCV) infection as a public health threat by 2030. Evidence that HCV treatment can lower viraemic prevalence among people who inject drugs (PWID) is limited. Broad accessibility of direct-acting antiviral (DAA) therapy in Australia, since March 2016, provides an opportunity to assess the efficacy of these treatments at a population level in a real-world setting. MethodsData from Australia’s annual bio-behavioural surveillance examined treatment uptake and estimated viraemic prevalence among PWID attending needle syringe programs nationally between 2015 and 2017. Multivariate logistic regression identified variables independently associated with HCV treatment among those considered eligible (anti-HCV positive excluding HCV RNA negative with no self-reported history of HCV treatment) in 2017. ResultsAnnual samples ranged from 1,995–2,380 PWID. Anti-HCV prevalence declined from 57% (2015) to 49% (2017, χ2ptrend <0.001), with 40–56% of anti-HCV positive respondents providing sufficient sample for HCV RNA testing. Between 2015 and 2017, treatment uptake among those eligible increased from 10% to 41% (χ2ptrend <0.001) and viraemic prevalence among the overall sample declined from 43% to 25% (χ2ptrend <0.001). In multivariable analysis, older age (≥50?years adjusted odds ratio [aOR] 1.82; 95% CI 1.09–3.06;p?=?0.023 and 44–49?years aOR 1.75; 95% CI 1.03–3.00;p?=?0.038vs.≤37?years) and history of opioid substitution therapy (aOR 2.06; 95% CI 1.30–3.26;p?=?0.002) were independently associated with treatment. ConclusionsThis study confirms PWID are willing to initiate treatment when HCV DAA therapy is available and provides population-level evidence of a decline in viraemic prevalence among people most at risk of ongoing HCV transmission. Scaled up surveillance and monitoring are required to evaluate progress toward WHO HCV elimination goals. Lay summaryThe World Health Organization’s goal to reduce hepatitis C virus incidence by 80% will be difficult to achieve without widespread scale up and a corresponding reduction in viraemic prevalence among those most at risk of onward transmission. Our results indicate that a population-level reduction in viraemic prevalence is achievable through high levels of treatment and cure among people who inject drugs....
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Background & AimsThe World Health Organization (WHO) established targets to eliminate hepatitis C virus (HCV) infection as a public health threat by 2030. Evidence that HCV treatment can lower viraemic prevalence among people who inject drugs (PWID) is limited. Broad accessibility of direct-acting antiviral (DAA) therapy in Australia, since March 2016, provides an opportunity to assess the efficacy of these treatments at a population level in a real-world setting. MethodsData from Australia’s annual bio-behavioural surveillance examined treatment uptake and estimated viraemic prevalence among PWID attending needle syringe programs nationally between 2015 and 2017. Multivariate logistic regression identified variables independently associated with HCV treatment among those considered eligible (anti-HCV positive excluding HCV RNA negative with no self-reported history of HCV treatment) in 2017. ResultsAnnual samples ranged from 1,995–2,380 PWID. Anti-HCV prevalence declined from 57% (2015) to 49% (2017, χ2ptrend <0.001), with 40–56% of anti-HCV positive respondents providing sufficient sample for HCV RNA testing. Between 2015 and 2017, treatment uptake among those eligible increased from 10% to 41% (χ2ptrend <0.001) and viraemic prevalence among the overall sample declined from 43% to 25% (χ2ptrend <0.001). In multivariable analysis, older age (≥50?years adjusted odds ratio [aOR] 1.82; 95% CI 1.09–3.06;p?=?0.023 and 44–49?years aOR 1.75; 95% CI 1.03–3.00;p?=?0.038vs.≤37?years) and history of opioid substitution therapy (aOR 2.06; 95% CI 1.30–3.26;p?=?0.002) were independently associated with treatment. ConclusionsThis study confirms PWID are willing to initiate treatment when HCV DAA therapy is available and provides population-level evidence of a decline in viraemic prevalence among people most at risk of ongoing HCV transmission. Scaled up surveillance and monitoring are required to evaluate progress toward WHO HCV elimination goals. Lay summaryThe World Health Organization’s goal to reduce hepatitis C virus incidence by 80% will be difficult to achieve without widespread scale up and a corresponding reduction in viraemic prevalence among those most at risk of onward transmission. Our results indicate that a population-level reduction in viraemic prevalence is achievable through high levels of treatment and cure among people who inject drugs.
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